Syphilitic paroxysmal cold haemoglobinuria. Case report and study of the Coombs test.
نویسندگان
چکیده
A case of congenital syphilis which presented with paroxysmal cold haemoglobinuria is described. The patient had aortic incompetence, and the significance of this finding is discussed. The Coombs test was studied, and positive results appear to be due to interaction between antiglobulin serum and complement adsorbed on to the test cells, this adsorption being promoted by the cold antibodies.
منابع مشابه
Idiopathic non-syphilitic paroxysmal cold haemoglobinuria in children.
Three examples of non-syphilitic paroxysmal cold haemoglobinuria (PCH) in children are described which occurred, within a period of 16 days, in association with a febrile illness. No definite viral aetiology or obvious epidemiological association could be established. A Donath-Landsteiner antibody of anti-P specificity was demonstrated in all three patients. The serological aspects of PCH are c...
متن کاملDiagnostic difficulties in a patient with paroxysmal cold haemoglobinuria and acute kidney injury
Paroxysmal cold haemoglobinuria (PCH) is a form of autoimmune haemolytic anaemia (AIHA) characterised by a sudden onset of haemoglobinuria, either spontaneously or following exposure to cold. In children, it is commonly seen following a viral illness or after immunisation. Diagnosis of PCH is confirmed by a positive Donath Landsteiner (DL) test in which biphasic haemolysins are detected. Howeve...
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With the increasing control of congenital syphilis, paroxysmal cold haemoglobinuria has become a very rare disorder in childhood. Cases which occur now are more likely to be associated with acute infectious diseases (Kissmeyer-Nielsen and Schleisner, 1963). However, despite the frequency of measles in children, paroxysmal cold haemoglobinuria (PCH) has only previously been described as a compli...
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Background: Paroxysmal cold hemoglobinuria (PCH), an autoimmune hemolytic anaemia caused due to polyclonal IgG anti-P autoantibody binding to red blood cell surface antigens and is characterized by hemoglobinuria, typically after exposure to cold temperatures. Case Presentation: An 84-year-old female patient started developing breathing difficulty off and on with generalised weakness and loss o...
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Abstract Background and objectives: ABO phenotyping is one of the essential tests in Immunohematology. Incompatible blood group transfusion leads to acute hemolysis reactions and other serious complications. Anti A1 is a cold Antibody with no clinical significance, but if it is reacted at 37˚c can be clinically significant, which will be happened rarely. At the present, we report a Case with a...
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عنوان ژورنال:
- Journal of clinical pathology
دوره 13 شماره
صفحات -
تاریخ انتشار 1960